Sulfate Conjugates Are Urinary Markers of Inhalation Exposure to 4-Chlorobiphenyl (PCB3)

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• 作者：Kiran Dhakal ; Andrea Adamcakova-Dodd ; Hans-Joachim Lehmler ; Peter S. Thorne ; Larry W. Robertson
• 刊名：Chemical Research in Toxicology
• 出版年：2013
• 出版时间：June 17, 2013
• 年：2013
• 卷：26
• 期：6
• 页码：853-855
• 全文大小：214K
• 年卷期：v.26,no.6(June 17, 2013)
• ISSN：1520-5010

文摘

PCBs are contaminants in the air of older buildings and cities, which raises the concern of inhalation exposure. No reliable biomarker of such exposure is available. We exposed rats to air containing 2 mg/m³ PCB3 via nose-only inhalation for 2 h, collected urine, and analyzed it by LC/MS. Each rat inhaled an estimated dose of 35 渭g PCB3, and excreted 27 卤 2% of it as sulfates within 24 h. Peak excretion occurred within 6 h. PCB sulfates were stable in urine for at least three days at room temperature without chemical preservatives. These data support the use of PCB sulfate conjugates as suitable urinary biomarkers of PCB3 and other airborne PCBs.