Shading the TRF2 Recruiting Function: A New Horizon in Drug Development

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• 作者：Salvatore Di Maro ; Pasquale Zizza ; Erica Salvati ; Viviana De Luca ; Clemente Capasso ; Iolanda Fotticchia ; Bruno Pagano ; Luciana Marinelli ; Eric Gilson ; Ettore Novellino ; Sandro Cosconati ; Annamaria Biroccio
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：December 3, 2014
• 年：2014
• 卷：136
• 期：48
• 页码：16708-16711
• 全文大小：312K
• ISSN：1520-5126

文摘

The shelterin protein TRF2 has come to the limelight for its role in telomere maintenance and tumorigenesis. Herein, the application of rational design and synthesis allowed identifying the first TRF2_TRFH binder able to elicit a marked DNA damage response in cancer cells. This work paves the way for the unprecedented employment of a chemical tool to finely tune specific mechanisms underlying telomere maintenance.