Changes in Serum Concentrations of Maternal Poly- and Perfluoroalkyl Substances over the Course of Pregnancy and Predictors of Exposure in a Multiethnic Cohort of Cincinnati, Ohio Pregnant Women durin

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• 作者：Kayoko Kato ; Lee-Yang Wong ; Aimin Chen ; Carmen Dunbar ; Glenys M. Webster ; Bruce P. Lanphear ; Antonia M. Calafat
• 刊名：Environmental Science & Technology
• 出版年：2014
• 出版时间：August 19, 2014
• 年：2014
• 卷：48
• 期：16
• 页码：9600-9608
• 全文大小：294K
• ISSN：1520-5851

文摘

Data on predictors of gestational exposure to poly- and perfluoroalkyl substances (PFASs) in the United States are limited. To fill in this gap, in a multiethnic cohort of Ohio pregnant women recruited in 2003鈥?006, we measured perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and six additional PFASs in maternal serum at 16 weeks gestation (N = 182) and delivery (N = 78), and in umbilical cord serum (N = 202). We used linear regression to examine associations between maternal serum PFASs concentrations and demographic, perinatal, and lifestyle factors. PFASs concentrations in maternal sera and in their infants鈥?cord sera were highly correlated (Spearman rank correlation coefficients = 0.73鈥?.95). In 71 maternal-infant dyads, unadjusted geometric mean (GM) concentrations (95% confidence interval) (in 渭g/L) in maternal serum at delivery of PFOS [8.50 (7.01鈥?.58)] and PFOA [3.43 (3.01鈥?.90)] were significantly lower than at 16 weeks gestation [11.57 (9.90鈥?3.53], 4.91 (4.32鈥?.59), respectively], but higher than in infants鈥?cord serum [3.32 (2.84鈥?.89), 2.85 (2.51鈥?.24), respectively] (P < 0.001). Women who were parous, with a history of previous breastfeeding, black, or in the lowest income category had significantly lower PFOS and PFOA GM concentrations than other women. These data suggest transplacental transfer of PFASs during pregnancy and nursing for the first time in a U.S. birth cohort.