Modulation of Small Molecule Induced Architecture of Cyclodextrin Aggregation by Guest Structure and Host Size

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• 作者：Prasun Ghosh ; Arnab Maity ; Tarasankar Das ; Jyotirmayee Dash ; Pradipta Purkayastha
• 刊名：Journal of Physical Chemistry C
• 出版年：2011
• 出版时间：November 3, 2011
• 年：2011
• 卷：115
• 期：43
• 页码：20970-20977
• 全文大小：1133K
• 年卷期：v.115,no.43(November 3, 2011)
• ISSN：1932-7455

文摘

A small molecule based on bisphenylethynyl amide meta linked to 2,6-pyridine can induce cyclodextrin (CD) aggregation through a possible 1:3 guest鈥揾ost motif. Most of the small molecules induce CD nanotubular bundles principally through 1:2 guest鈥揾ost unit capsules and aggregate through hydrogen bonding among the hydroxyl groups present on the rims of the CD molecules. The N,N-dimethyl aminopropyl carboxamide side chain and the central pyridine ring of 6-bromo-2-phenylethylaminopyridine (BPEAP) induces nanotubular bundles with 伪-CD and laminar bundles with 尾- and 纬-CDs, which, as a consequence, may result in formation of pores in the aggregates that can find wide applications in biological storage machinery. The stoichiometry of the ingredients of the unit capsules has been evidenced by Job鈥檚 plot. The size-dependent suprastructures induced by BPEAP have been studied by steady state and time-resolved fluorescence spectroscopy and atomic force microscopy.