One-Pot Synthesis of Benzothiazole-Tethered Chromanones/Coumarins via Claisen Rearrangement Using the Solid State Melt Reaction

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• 作者：Manickam Bakthadoss ; Raman Selvakumar
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：April 15, 2016
• 年：2016
• 卷：81
• 期：8
• 页码：3391-3399
• 全文大小：539K
• 年卷期：0
• ISSN：1520-6904

文摘

A novel protocol has been successfully established for the efficient synthesis of benzothiazole-tethered chromanone/coumarin scaffolds via Claisen rearrangement using a solid state melt reaction in a one-pot manner. Benzothiazole formation and Claisen rearrangement involve the cleavage of S–S and C–O bonds and formation of C–S, C═N, and C–C bonds in a single operation without using a catalyst or solvent.