Rh-Catalyzed Highly Enantioselective Hydroalkynylation Reaction of Norbornadiene Derivatives

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• 作者：Baomin Fan ; Jianbin Xu ; Qingjing Yang ; Sifeng Li ; Hualei Chen ; Shanshan Liu ; Lu Yu ; Yongyun Zhou ; Lin Wang
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：December 6, 2013
• 年：2013
• 卷：15
• 期：23
• 页码：5956-5959
• 全文大小：267K
• 年卷期：v.15,no.23(December 6, 2013)
• ISSN：1523-7052

文摘

The complexes of various Rh precusors with ferrocenyl chiral ligand (R,S)-Cy₂PF-PPh₂ were found effective catalysts for the asymmetric hydroalkynylation reaction of norbornadiene derivatives. When RhCl₃路3H₂O was employed, good yields (up to 98%) and high enantioselectivities (up to >99.9% ee) could be obtained for the reactions of a broad scope of substrates.