Ruthenium-Catalyzed (2 + 2) Intramolecular Cycloaddition of Allenenes

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• 作者：Mois茅s Gul铆as ; Alba Collado ; Beatriz Trillo ; Fernando L贸pez ; Enrique O帽ate ; Miguel A. Esteruelas ; Jos茅 L. Mascare帽as
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：May 25, 2011
• 年：2011
• 卷：133
• 期：20
• 页码：7660-7663
• 全文大小：789K
• 年卷期：v.133,no.20(May 25, 2011)
• ISSN：1520-5126

文摘

We report a ruthenium-catalyzed (2 + 2) intramolecular cycloaddition of allenes and alkenes. We have found that the use of the ruthenium complex RuH₂Cl₂(PⁱPr₃)₂, which has previously gone unnoticed in catalytic applications, is crucial for the observed reactivity. The reaction proceeds under mild conditions and is fully diastereoselective, providing a practical entry to a variety of bicyclo[3.2.0]heptane skeletons featuring cyclobutane rings.