Protease-Sensitive Fluorescent Nanofibers

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• 作者：Benedict Law ; Ralph Weissleder ; Ching-Hsuan Tung
• 刊名：Bioconjugate Chemistry
• 出版年：2007
• 出版时间：November 2007
• 年：2007
• 卷：18
• 期：6
• 页码：1701 - 1704
• 全文大小：950K
• 年卷期：v.18,no.6(November 2007)
• ISSN：1520-4812

文摘

We report the design and synthesis of enzyme-responsive nanofibers. The fibers are composed of self-assembled hydrophobic β-sheet peptides incorporating protease-sensitive domains, fluorescent reporters, and hydrophilic poly(ethylene glycol) (PEG) units. Using urokinase plasminogen activator (uPA) as a model system, nanofibers were developed to release fluorescent fragments upon uPA incubation. These protease-sensitive nanofibers may have considerable biomedical applications as diagnostic sensors or for protease-assisted drug deliveries.