Silver-Catalyzed Tandem Hydroamination/Hydroarylation of 1-(2-Allylamino)phenyl-4-hydroxy-but-2-yn-1-ones to 1鈥?Allylspiro[indene-1,2鈥?indolin]-3鈥?ones

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• 作者：Srinivasa Reddy Mothe ; Maria Laurentia Novianti ; Benjamin James Ayers ; Philip Wai Hong Chan
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：August 15, 2014
• 年：2014
• 卷：16
• 期：16
• 页码：4110-4113
• 全文大小：285K
• ISSN：1523-7052

文摘

An efficient silver triflate-catalyzed tandem hydroamination/hydroarylation cascade generating 1鈥?allylspiro[indene-1,2鈥?indolin]-3鈥?ones from 1-(2-allylamino)phenyl-4-hydroxy-but-2-yn-1-ones is described. The reaction conditions are mild and general in scope and proceed to highly functionalized spiro-targets in high yield. This novel class of molecule possesses both the privileged indene and indolin-3-one scaffold, which may lead to possible pharmacological applications.