Poly(oligo(ethylene glycol) methyl ether methacrylate) Brushes on High-κ Metal Oxide Dielectric Surfaces for Bioelectrical Environments

详细信息    查看全文

• 作者：Daniel Y. Joh ; Felicia McGuire ; Roozbeh Abedini-Nassab ; Joseph B. Andrews ; Rohan K. Achar ; Zackary Zimmers ; Darush Mozhdehi ; Rebecca Blair ; Faris Albarghouthi ; William Oles ; Jacob Richter ; Cassio M. Fontes ; Angus M. Hucknall ; Benjamin B. Yellen ; Aaron D. Franklin ; Ashutosh Chilkoti
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2017
• 出版时间：February 15, 2017
• 年：2017
• 卷：9
• 期：6
• 页码：5522-5529
• 全文大小：446K
• ISSN：1944-8252

文摘

Advances in electronics and life sciences have generated interest in “lab-on-a-chip” systems utilizing complementary metal oxide semiconductor (CMOS) circuitry for low-power, portable, and cost-effective biosensing platforms. Here, we present a simple and reliable approach for coating “high-κ” metal oxide dielectric materials with “non-fouling” (protein- and cell-resistant) poly(oligo(ethylene glycol) methyl ether methacrylate (POEGMA) polymer brushes as biointerfacial coatings to improve their relevance for biosensing applications utilizing advanced electronic components. By using a surface-initiated “grafting from” strategy, POEGMA films were reliably grown on each material, as confirmed by ellipsometric measurements and X-ray photoelectron spectroscopy (XPS) analysis. The electrical behavior of these POEGMA films was also studied to determine the potential impact on surrounding electronic devices, yielding information on relative permittivity and breakdown field for POEGMA in both dry and hydrated states. We show that the incorporation of POEGMA coatings significantly reduced levels of nonspecific protein adsorption compared to uncoated high-κ dielectric oxide surfaces as shown by protein resistance assays. These attributes, combined with the robust dielectric properties of POEGMA brushes on high-κ surfaces open the way to incorporate this protein and cell resistant polymer interface into CMOS devices for biomolecular detection in a complex liquid milieu.