Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo
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- 作者：Yizhou Dong ; J. Robert Dorkin ; Weiheng Wang ; Philip H. Chang ; Matthew J. Webber ; Benjamin C. Tang ; Junghoon Yang ; Inbal Abutbul-Ionita ; Dganit Danino ; Frank DeRosa ; Michael Heartlein ; Robert Langer ; Daniel G. Anderson
- 刊名：Nano Letters
- 出版年：2016
- 出版时间：February 10, 2016
- 年：2016
- 卷：16
- 期：2
- 页码：842-848
- 全文大小：433K
- ISSN：1530-6992
文摘
Safe and effective delivery is required for siRNA and mRNA-based therapeutics to reach their potential. Here, we report on the development of poly(glycoamidoamine) brush nanoparticles as delivery vehicles for siRNA and mRNA. These polymers were capable of significant delivery of siRNA against FVII and mRNA-encoding erythropoietin (EPO) in mice. Importantly, these nanoparticles were well-tolerated at their effective dose based on analysis of tissue histology, systemic cytokine levels, and liver enzyme chemistry. The polymer brush nanoparticles reported here are promising for therapeutic applications.