Utilization of SABRE-Derived Hyperpolarization To Detect Low-Concentration Analytes via 1D and 2D NMR Methods

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• 作者：Lyrelle S. Lloyd ; Ralph W. Adams ; Michael Bernstein ; Steven Coombes ; Simon B. Duckett ; Gary G. R. Green ; Richard. J. Lewis ; Ryan E. Mewis ; Christopher J. Sleigh
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：August 8, 2012
• 年：2012
• 卷：134
• 期：31
• 页码：12904-12907
• 全文大小：244K
• 年卷期：v.134,no.31(August 8, 2012)
• ISSN：1520-5126

文摘

The characterization of materials by the inherently insensitive method of NMR spectroscopy plays a vital role in chemistry. Increasingly, hyperpolarization is being used to address the sensitivity limitation. Here, by reference to quinoline, we illustrate that the SABRE hyperpolarization technique, which uses para-hydrogen as the source of polarization, enables the rapid completion of a range of NMR measurements. These include the collection of ¹³C, ¹³C{¹H}, and NOE data in addition to more complex 2D COSY, ultrafast 2D COSY and 2D HMBC spectra. The observations are made possible by the use of a flow probe and external sample preparation cell to re-hyperpolarize the substrate between transients, allowing repeat measurements to be made within seconds. The potential benefit of the combination of SABRE and 2D NMR methods for rapid characterization of low-concentration analytes is therefore established.