Isolation and Structure Elucidation of Pentahydroxyscirpene, a Trichothecene Fusarium Mycotoxin

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• 作者：Philipp Fruhmann ; Hannes Mikula ; Gerlinde Wiesenberger ; Elisabeth Varga ; Daniel Lumpi ; Berthold St?ger ; Georg H?ubl ; Marc Lemmens ; Franz Berthiller ; Rudolf Krska ; Gerhard Adam ; Christian Hametner ; Johannes Fr?hlich
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：January 24, 2014
• 年：2014
• 卷：77
• 期：1
• 页码：188-192
• 全文大小：389K
• ISSN：1520-6025

文摘

Pentahydroxyscirpene, a novel trichothecene-type compound, was isolated from Fusarium-inoculated rice. The structure of pentahydroxyscirpene was elucidated by 1D and 2D NMR spectroscopy and X-ray single-crystal diffraction. The conformation in solution was determined by NOESY experiments supported by quantum chemical calculations. In vitro toxicity tests showed that pentahydroxyscirpene inhibits protein synthesis as do other trichothecenes.