Self-Assembly of Conjugated Polymer on Hybrid Nanospheres for Cellular Imaging Applications
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- 作者：Bihua Xia ; Xiaoyu Wang ; Fang He ; Qianling Cui ; Lidong Li
- 刊名：ACS Applied Materials & Interfaces
- 出版年：2012
- 出版时间：November 28, 2012
- 年：2012
- 卷：4
- 期：11
- 页码：6332-6337
- 全文大小：318K
- 年卷期：v.4,no.11(November 28, 2012)
- ISSN：1944-8252
文摘
A new kind of hybrid core鈥搒hell nanosphere was fabricated by combining the in situ formation of Au nanoparticles and covalent cross-linking of biocompatible carboxymethyl starch dialdehyde (CMSD) and chitosan (CTS). When the fluorescent dye poly[9,9鈥?bis(6鈥?(N,N,N-trimethylammonium)-hexyl)fluorene-2,7-ylenevinylene-co-alt-1,4-phenylene dibromide] (PFV) was assembled on the surface of the hybrid nanospheres through electrostatic attraction, these biocompatible hybrid nanospheres exhibited metal-enhanced fluorescence effects. The fluorescence intensity of (CTS鈥揂u)@CMSD/PFV hybrid nanosphere is 1.43 times that of CTS鈥揅MSD/PFV hybrid nanospheres lacking Au nanoparticle. In addition, the (CTS鈥揂u)@CMSD/PFV hybrid nanospheres exhibit excellent biodegradability upon exposure to enzymatic aqueous solution and good biocompatibility when cocultured with HeLa cervical carcinoma cells; these advantages make them attractive for cellular imaging and biological analysis and detection.