Bahamaolides A and B, Antifungal Polyene Polyol Macrolides from the Marine Actinomycete Streptomyces sp.

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• 作者：Dong-Gyu Kim ; Kyuho Moon ; Seong-Hwan Kim ; Seon-Hui Park ; Sunghyouk Park ; Sang Kook Lee ; Ki-Bong Oh ; Jongheon Shin ; Dong-Chan Oh
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：May 25, 2012
• 年：2012
• 卷：75
• 期：5
• 页码：959-967
• 全文大小：378K
• 年卷期：v.75,no.5(May 25, 2012)
• ISSN：1520-6025

文摘

Bahamaolides A and B (1 and 2), two new 36-membered macrocyclic lactones, were isolated from the culture of the marine actinomycete Streptomyces sp. derived from a sediment sample collected at North Cat Cay in the Bahamas. The planar structures of 1 and 2, bearing a hexaenone and nine consecutive skipped hydroxy groups, were determined by 1D and 2D NMR, mass, IR, and UV spectra. The absolute configurations of the bahamaolides were established by combined multistep chemical reactions and spectroscopic analysis. Bahamaolide A displayed significant inhibitory activity against Candida albicans isocitrate lyase and antifungal activity against various pathogenic fungi.