Au-Catalyzed Piperidine Synthesis via Tandem Acyloxy Migration/Intramolecular [3 + 2] Cycloaddition of Enynyl Esters

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• 作者：Huaiji Zheng ; Xing Huo ; Changgui Zhao ; Peng Jing ; Juan Yang ; Bowen Fang ; Xuegong She
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：December 16, 2011
• 年：2011
• 卷：13
• 期：24
• 页码：6448-6451
• 全文大小：776K
• 年卷期：v.13,no.24(December 16, 2011)
• ISSN：1523-7052

文摘

An Au-catalyzed tandem protocol involving enynyl ester isomerization and subsequent intramolecular [3 + 2] cyclization has been developed. This strategy provides an efficient approach for the synthesis of polyfunctional piperidines, which are subunits of many bioactive molecules.