Copper-Catalyzed [18F]Fluorination of (Mesityl)(aryl)iodonium Salts

详细信息    查看全文

• 作者：Naoko Ichiishi ; Allen F. Brooks ; Joseph J. Topczewski ; Melissa E. Rodnick ; Melanie S. Sanford ; Peter J. H. Scott
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：June 20, 2014
• 年：2014
• 卷：16
• 期：12
• 页码：3224-3227
• 全文大小：261K
• 年卷期：v.16,no.12(June 20, 2014)
• ISSN：1523-7052

文摘

A practical, rapid, and highly regioselective Cu-catalyzed radiofluorination of (mesityl)(aryl)iodonium salts is described. This protocol utilizes [¹⁸F]KF to access ¹⁸F-labeled electron-rich, -neutral, and -deficient aryl fluorides under a single set of mild conditions. This methodology is applied to the synthesis of protected versions of two important radiotracers: 4-[¹⁸F]fluorophenylalanine and 6-[¹⁸F]fluoroDOPA.