Antiproliferative Activity of trans-Avicennol from Zanthoxylum chiloperone var. angustifolium against Human Cancer Stem Cells
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- 作者：Gerardo Cebri谩n-Torrej贸n ; Suzana Assad Kahn ; Nathalie Lagarde ; Flavia Castellano ; Karine Leblanc ; Jordi Rodrigo ; Val茅rie Molinier-Frenkel ; Antonieta Rojas de Arias ; Maria Elena Ferreira ; C茅cile Thirant ; Alain Fournet ; Bruno Figad猫re ; Herv茅 Chneiweiss ; Erwan Poupon
- 刊名：Journal of Natural Products
- 出版年：2012
- 出版时间：February 24, 2012
- 年：2012
- 卷：75
- 期：2
- 页码：257-261
- 全文大小：235K
- 年卷期：v.75,no.2(February 24, 2012)
- ISSN：1520-6025
文摘
Zanthoxylum chiloperone var. angustifolium root bark was studied with the aim of finding novel molecules able to overcome cancer stem cell chemoresistance. Purification of a methanol-soluble extract resulted in the isolation of a known pyranocoumarin, trans-avicennol (1). Compound 1 demonstrated antiproliferative activity on glioma-initiating cells, whereas it was inactive on human neural stem cells. trans-Avicennol (1) activated the MAPK/ERK pathway and was also evaluated for its ability to inhibit the enzyme indoleamine-2,3-dioxygenase.