Cytotoxicity and NMR Studies of Platinum Complexes with Cyclooctadiene Ligands

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• 作者：Mirja Enders ; Benjamin G枚rling ; Alexander B. Braun ; Judith E. Seltenreich ; Linus F. Reichenbach ; Kari Rissanen ; Martin Nieger ; Burkhard Luy ; Ute Schepers ; Stefan Br盲se
• 刊名：Organometallics
• 出版年：2014
• 出版时间：August 11, 2014
• 年：2014
• 卷：33
• 期：15
• 页码：4027-4034
• 全文大小：355K
• ISSN：1520-6041

文摘

The synthesis of a series of platinum complexes containing cyclooctadiene ligands with the general structure PtMeL(R-cod) (where L = Cl, I, nC₃F₇, iC₃F₇, nC₈F₁₇, Me, aryl, alkynyl and R = H, Me, Et, iPr, nBu, iBu, nHex, Ph) is presented. All complexes are remarkably stable and were obtained in excellent yields. Their structure in both solution and the solid state were explored by crystal structures and multinuclear (¹H, ¹³C, ¹⁹F, ¹⁹⁵Pt) NMR spectroscopy. Cytotoxicity experiments with selected complexes in HeLa cells revealed higher toxicity in comparison to that of cisplatin for most of the structures.