Palladium-Catalyzed Benzylic Arylation of Pyridylmethyl Silyl Ethers: One-Pot Synthesis of Aryl(pyridyl)methanols
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- 作者：Alexandra R. Rivero ; Byeong-Seon Kim ; Patrick J. Walsh
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：April 1, 2016
- 年：2016
- 卷：18
- 期：7
- 页码：1590-1593
- 全文大小：395K
- ISSN：1523-7052
文摘
An efficient palladium-catalyzed direct arylation of pyridylmethyl silyl ethers with aryl bromides is described. A Pd(OAc)2/NIXANTPHOS-based catalyst provides aryl(pyridyl)methyl alcohol derivatives in good to excellent yields (33 examples, 57–100% yield). This protocol is compatible with different silyl ether protecting groups, affording either the protected or the free alcohols in an effective one-pot process. The scalability of the reaction is demonstrated.