Specific Pathways of Dietary Methylmercury and Inorganic Mercury Determined by Mercury Speciation and Isotopic Composition in Zebrafish (Danio rerio)

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• 作者：Caiyan Feng ; Zoyne Pedrero ; Sophie Gent猫s ; Julien Barre ; Marina Renedo ; Emmanuel Tessier ; Sylvain Berail ; R茅gine Maury-Brachet ; Nathalie Mesmer-Dudons ; Magalie Baudrimont ; Alexia Legeay ; Laurence Maurice ; Patrice Gonzalez ; David Amouroux
• 刊名：Environmental Science & Technology
• 出版年：2015
• 出版时间：November 3, 2015
• 年：2015
• 卷：49
• 期：21
• 页码：12984-12993
• 全文大小：497K
• ISSN：1520-5851

文摘

An original approach is proposed to investigate inorganic (iHg) and methylmercury (MeHg) trophic transfer and fate in a model fish, Danio rerio, by combining natural isotopic fractionation and speciation. Animals were exposed to three different dietary conditions: (1) 50 ng Hg g^鈥?, 80% as MeHg; (2) diet enriched in MeHg 10鈥?00 ng Hg g^鈥?, 95% as MeHg, and (3) diet enriched in iHg 10鈥?00 ng Hg g^鈥?, 99% as iHg. Harvesting was carried out after 0, 7, 25, and 62 days. Time-dependent Hg species distribution and isotopic fractionation in fish organs (muscle, brain, liver) and feces, exhibited different patterns, as a consequence of their dissimilar metabolization. The rapid isotopic re-equilibration to the new MeHg-food source reflects its high bioaccumulation rate. Relevant aspects related to Hg excretion are also described. This study confirms Hg isotopic fractionation as a powerful tool to investigate biological processes, although its deconvolution and fully understanding is still a challenge.