Electrostatically Mediated Liposome Fusion and Lipid Exchange with a Nanoparticle-Supported Bilayer for Control of Surface Charge, Drug Containment, and Delivery

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• 作者：Juewen Liu ; Xingmao Jiang ; Carlee Ashley ; C. Jeffrey Brinker
• 刊名：Journal of the American Chemical Society
• 出版年：2009
• 出版时间：June 10, 2009
• 年：2009
• 卷：131
• 期：22
• 页码：7567-7569
• 全文大小：252K
• 年卷期：v.131,no.22(June 10, 2009)
• ISSN：1520-5126

文摘

The loading and containment of cargo within nanoparticles and their efficient delivery to cells represent a primary challenge in nanomedicine. We report lipid exchange between free and mesoporous silica nanoparticle-supported lipid bilayers as an effective means of containing cargo, controlling charge, and directing delivery to mammalian cells. The delivery of a membrane-impermeable dye (calcein) and a chemotherapeutic drug (doxorubicin) are demonstrated. Exchanged lipid bilayers minimized premature drug release, and an overall positive charge on the supported lipid bilayer effected enhanced delivery.