ent-Labdane Diterpenoids from the Aerial Parts of Eupatorium obtusissmum

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• 作者：Quírico A. Castillo ; Jorge Triana ; José L. Eiroa ; Laurent Calcul ; Edwin Rivera ; Lukasz Wojtas ; José M. Padrón ; Lise Boberieth ; Mehdi Keramane ; Ernesto Abel-Santos ; Luis A. Báez ; Evelyn A. Germosén
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：April 22, 2016
• 年：2016
• 卷：79
• 期：4
• 页码：907-913
• 全文大小：370K
• 年卷期：0
• ISSN：1520-6025

文摘

Six new ent-labdane diterpenoids, uasdlabdanes A–F (1–6), were isolated from the aerial parts of Eupatorium obtusissmum. The new structures were elucidated through spectroscopic and spectrometric data analyses. The absolute configurations of compounds 1 and 2 were established by X-ray crystallography, and those of 3–6, by comparison of experimental and calculated electronic circular dichroism spectra. The antiproliferative activity of the compounds was studied in a panel of six representative human solid tumor cell lines and showed GI₅₀ values ranging from 19 to >100 μM.