Cytotoxic Alkylpiperidine Alkaloids from the Brazilian Marine Sponge Pachychalina alcaloidifera
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- 作者：Jaine H. H. L. de Oliveira ; André ; a M. Nascimento ; Miriam H. Kossuga ; Bruno C. Cavalcanti ; Claudia O. Pessoa ; Manoel O. Moraes ; Mario L. Macedo ; Antonio G. Ferreira ; Eduardo Hajdu ; Ulisses S. Pi
- 刊名：Journal of Natural Products
- 出版年：2007
- 出版时间：April 2007
- 年：2007
- 卷：70
- 期：4
- 页码：538 - 543
- 全文大小：84K
- 年卷期：v.70,no.4(April 2007)
- ISSN：1520-6025
文摘
Four bis-piperidine alkaloids, madangamine F (1), haliclonacyclamine F (2). and arenosclerins D (3) and E (4), havebeen isolated from the marine sponge Pachychalina alcaloidifera and have been identified by analysis of spectroscopicdata. The alkaloids displayed cytotoxic activity against different cancer cell lines. These results support the hypothesisof a common biogenetic origin for the Haplosclerida bis-piperidine and bis-pyridine alkaloids.