Easily Accessible and Highly Tunable Indolyl Phosphine Ligands for Suzuki-Miyaura Coupling of Aryl Chlorides

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• 作者：Chau Ming So ; Chak Po Lau ; Fuk Yee Kwong
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：July 19, 2007
• 年：2007
• 卷：9
• 期：15
• 页码：2795 - 2798
• 全文大小：123K
• 年卷期：v.9,no.15(July 19, 2007)
• ISSN：1523-7052

文摘

This study describes a new class of easily accessible indolyl phosphine ligands, prepared via an efficient protocol involving Fischer indolizationfrom readily available phenylhydrazine and substituted acetophenones. This versatile ligand scaffold provides beneficial features, includinghigh potential of steric and electronic tunability. The air-stable indolyl phosphines in combination with a palladium metal precursor providehighly effective catalysts for Suzuki-Miyaura coupling of unactivated aryl chlorides, and the catalyst loading down to 0.02 mol % can beachieved.