Amphiphilic Copolymers Capable of Concomitant Release of HNO and Small Molecule Organics

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• 作者：Derek C. Church ; Saghar Nourian ; Chang-Uk Lee ; Neal A. Yakelis ; John P. Toscano ; Andrew J. Boydston
• 刊名：ACS Macro Letters
• 出版年：2017
• 出版时间：January 17, 2017
• 年：2017
• 卷：6
• 期：1
• 页码：46-49
• 全文大小：357K
• ISSN：2161-1653

文摘

We demonstrate concomitant release of HNO and small molecule organics from amphiphilic poly(norbornene)-based copolymers. This key function was achieved by incorporation of thermally labile oxazine units within random and block copolymer architectures. Upon thermolysis, we observed generation of HNO and release of a small molecule conjugate. Importantly, the release kinetics of HNO and a UV-active small molecule (4-nitroaniline) were found to be 1:1, signifying an ability to monitor HNO production indirectly, or to simultaneously release organic therapeutics (e.g., nonsteroidal anti-inflammatory drugs) along with HNO. To our knowledge, these are the first reported polymeric materials demonstrating HNO release from covalently attached HNO donors.