New Electrophilic Addition of 伪-Diazoesters with Ketones for Enantioselective C鈥揘 Bond Formation

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• 作者：Wei Li ; Xiaohua Liu ; Xiaoyu Hao ; Xiaolei Hu ; Yangyang Chu ; Weidi Cao ; Song Qin ; Changwei Hu ; Lili Lin ; Xiaoming Feng
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：October 5, 2011
• 年：2011
• 卷：133
• 期：39
• 页码：15268-15271
• 全文大小：800K
• 年卷期：v.133,no.39(October 5, 2011)
• ISSN：1520-5126

文摘

伪-Diazoesters were discovered to be good electrophiles in a catalytic asymmetric 伪-functionalization of ketones for the first time. This reaction also provided a direct and efficient method for C鈥揘 bond formation with excellent yields (up to 98%) and enantioselectivities (up to 99% ee) under mild conditions. The application of the electrophilicity of 伪-diazoesters opens up a novel way to access the diversity of diazo chemistry.