CuI-Catalyzed C鈥揘 Bond Formation and Cleavage for the Synthesis of Benzimidazo[1,2-a]quinazoline Derivatives

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• 作者：Chao Li ; Wen-Ting Zhang ; Xiang-Shan Wang
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：June 20, 2014
• 年：2014
• 卷：79
• 期：12
• 页码：5847-5851
• 全文大小：288K
• 年卷期：v.79,no.12(June 20, 2014)
• ISSN：1520-6904

文摘

A copper(I)-catalyzed domino reaction of N-(2-benzimidazolyl)-2-aminobenzamide and 2-halogenated benzaldehyde has been studied. The procedure is based on a sequential CuI-catalyzed Ullmann reaction (C鈥揘 bond formation) and two bond cleavage reactions and provides an efficient strategy for the synthesis of benzimidazo[1,2-a]quinazolines catalyzed by CuI/l-proline.