Practical Cross-Coupling between O-Based Electrophiles and Aryl Bromides via Ni Catalysis

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• 作者：Zhi-Chao Cao ; Qin-Yu Luo ; Zhang-Jie Shi
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：December 2, 2016
• 年：2016
• 卷：18
• 期：23
• 页码：5978-5981
• 全文大小：398K
• ISSN：1523-7052

文摘

Cross-coupling of various O-based electrophiles with aryl bromides was developed through Ni-catalyzed C–O activation in the presence of magnesium. Beside carboxylates, carbamates, and ethers, phenols exhibited excellent reactivity under modified conditions. This chemistry was featured as a simple and environmentally benign process with low catalyst loading and easy manipulations. The method exhibited broad substrate scopes.