Hypophyllins A–D, Labdane-Type Diterpenoids with Vasorelaxant Activity from Hypoestes phyllostachya “Rosea”Xing-De Wu, Dan Luo, Wen-Chao Tu, Zhen-Tao Deng, Xue-Jiao Chen, Jia Su, Xu Ji, and Qin-Shi Zhaopp 6484–6487Publication Date (Web): December 1, 2016 (Letter)DOI: 10.1021/acs.orglett.6b

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• 刊名：Organic Letters
• 出版年：2016
• 出版时间：December 16, 2016
• 年：2016
• 卷：18
• 期：24
• 全文大小：307K
• ISSN：1523-7052

文摘

Three rearranged labdane-type diterpenoids, hypophyllins A–C (1–3), and a caged labdane diterpenoid possessing a 8,9-dioxatricyclic[4.2.1.1^3,7]decane moiety, hypophyllin D (4), as well as two new biogenetically related diterpernoids, hypophyllins E (5) and F (6), were isolated from the aerial parts of <i>Hypoestes phyllostachyai> “Rosea”. The absolute configurations of 1–4 were determined by X-ray diffraction analysis. The plausible biogenetic pathway for 1–4 was also proposed. Compounds 4 and 5 showed potent vasorelaxant activity on endothelium-intact thoracic aorta rings precontracted with KCl.