Alkaloids with Different Carbon Units from Myrioneuron faberi

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• 作者：Ming-Ming Cao ; Yu Zhang ; Sheng-Dian Huang ; Ying-Tong Di ; Zong-Gen Peng ; Jian-Dong Jiang ; Chun-Mao Yuan ; Duo-Zhi Chen ; Shun-Lin Li ; Hong-Ping He ; Xiao-Jiang Hao
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：November 25, 2015
• 年：2015
• 卷：78
• 期：11
• 页码：2609-2616
• 全文大小：468K
• ISSN：1520-6025

文摘

Three new Myrioneuron alkaloids, myrifamines A鈥揅 (1鈥?b>3), with unique skeletons were isolated from Myrioneuron faberi. The absolute configuration of 1 was confirmed by single-crystal X-ray diffraction analysis, and the stereochemistry of the other two alkaloids was determined using a combination of ROESY experiments and calculated and experimental electronic circular dichroism spectra. Myrifamine C (3) is the first example of a symmetric dimer among the Myrioneuron alkaloids. Known alkaloids myrionamide (4) and schoberine (5) were also isolated, and experimental NMR and X-ray diffraction data suggest their structural revision. Compound 2 showed significant inhibitory activity toward the hepatitis C virus in vitro, with a therapeutic index (CC₅₀/EC₅₀) greater than 108.7.