Acyl and Silyl Group Effects in Reactivity-Based One-Pot Glycosylation: Synthesis of Embryonic Stem Cell Surface Carbohydrates Lc4 and IV2Fuc-Lc4

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• 作者：Yun Hsu ; Xin-An Lu ; Medel Manuel L. Zulueta ; Chih-Ming Tsai ; Kuo-I Lin ; Shang-Cheng Hung ; Chi-Huey Wong
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：March 14, 2012
• 年：2012
• 卷：134
• 期：10
• 页码：4549-4552
• 全文大小：298K
• 年卷期：v.134,no.10(March 14, 2012)
• ISSN：1520-5126

文摘

Relative reactivity evaluations showed the graded arming of toluenyl thioglucosides by variously positioned silyl groups but not by their acyl counterparts. These findings were applied in reactivity-based one-pot assembly of linker-attached Lc₄ and IV²Fuc-Lc₄, which are components of human embryonic stem cell surface. The sugar鈥揼alectin-1 binding was also examined.