A Thermoresponsive Bubble-Generating Liposomal System for Triggering Localized Extracellular Drug Delivery
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- 作者：Ko-Jie Chen ; Hsiang-Fa Liang ; Hsin-Lung Chen ; Yucai Wang ; Po-Yuan Cheng ; Hao-Li Liu ; Younan Xia ; Hsing-Wen Sung
- 刊名：ACS Nano
- 出版年：2013
- 出版时间：January 22, 2013
- 年：2013
- 卷：7
- 期：1
- 页码：438-446
- 全文大小：699K
- 年卷期：v.7,no.1(January 22, 2013)
- ISSN：1936-086X
文摘
The therapeutic effectiveness of chemotherapy is optimal only when tumor cells are subjected to a maximum drug exposure. To increase the intratumoral drug concentration and thus the efficacy of chemotherapy, a thermoresponsive bubble-generating liposomal system is proposed for triggering localized extracellular drug delivery. The key component of this liposomal formulation is the encapsulated ammonium bicarbonate (ABC), which is used to create the transmembrane gradient needed for a highly efficient encapsulation of doxorubicin (DOX). At an elevated temperature (42 掳C), decomposition of ABC generates CO2 bubbles, creating permeable defects in the lipid bilayer that rapidly release DOX and instantly increase the drug concentration locally. Because the generated CO2 bubbles are hyperechogenic, they also enhance ultrasound imaging. Consequently, this new liposomal system encapsulated with ABC may also provide an ability to monitor a temperature-controlled drug delivery process.