A New Route to Indazolone via Amidation Reaction of o-Carboxyazobenzene

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• 作者：Chengjie Li ; Tianyi Zhang ; Zhe Zeng ; Xiujun Liu ; Yunfeng Zhao ; Bao Zhang ; Yaqing Feng
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：January 20, 2012
• 年：2012
• 卷：14
• 期：2
• 页码：479-481
• 全文大小：210K
• 年卷期：v.14,no.2(January 20, 2012)
• ISSN：1523-7052

文摘

One new route for the synthesis of amino-substituted indazol-3,5-dione via the amidation reaction of o-carboxyazobenzenes is reported. Optimization which includes effects of the solvents, molar ratio of starting materials, and dehydrating agents on this reaction has been studied. A possible reaction mechanism has been proposed on the basis of the product鈥檚 structure, and the steric hindrance could be the main reason for low yield.