Enhancement of the Cytotoxicity and Selectivity of Doxorubicin to Hepatoma Cells by Synergistic Combination of Galactose-Decorated 纬-Poly(glutamic acid) Nanoparticles and Low-Intensity Ultrasound

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• 作者：Wei-Bor Tsai ; Hsin-Yu Lai ; Jyun-Lin Lee ; Chia-Wen Lo ; Wen-Shiang Chen
• 刊名：Langmuir
• 出版年：2014
• 出版时间：May 20, 2014
• 年：2014
• 卷：30
• 期：19
• 页码：5510-5517
• 全文大小：376K
• 年卷期：v.30,no.19(May 20, 2014)
• ISSN：1520-5827

文摘

Specific drug delivery to solid tumors remains one of the challenges in cancer therapy. The aim of this study was to combine three drug-targeting strategies, polymer-drug conjugate, ligand presentation and ultrasound treatment, to enhance the efficacy and selectivity of doxorubicin (DXR) to hepatoma cells. The conjugation of DXR to 纬-poly(glutamic acids) (纬-PGA) decreased the cytotoxicity of DXR, while the conjugation of galactosamine (Gal) to the 纬-PGA鈥揇XR conjugate restored the cytotoxic efficacy of DXR on hepatoma cells due to increased uptake of DXR. Furthermore, low-intensity ultrasound treatment increased the cell-killing ability of 纬-PGA鈥揇XR conjugates by 20%. The in vitro results showed the potential of the 纬-PGA鈥揇XR鈥揋al conjugate for future clinical applications.