seco-Abietane Diterpenoids, a Phenylethanoid Derivative, and Antitubercular Constituents from Callicarpa pilosissima
文摘
Six new compounds, including five new seco-abietane diterpenoids, 12-deoxy-seco-hinokiol methyl ester (1), 12-deoxy-11,12-dihydro-seco-hinokiol methyl ester (2), callicarpic acid A (3), 9α-hydroxycallicarpic acid A (4), and callicarpic acid B (5), and a new phenylethanoid derivative, 4-hydroxyphenethyl tetradecanoate (6), have been isolated from the leaves and twigs of Callicarpa pilosissima, together with 14 known compounds (7−20). The structures of these new compounds were determined through analyses of physical data. 12-Deoxy-11,12-dihydro-seco-hinokiol methyl ester (2), callicarpic acid B (5), and α-tocopherol trimer B (15) exhibit antitubercular activities (MICs ≤ 63.6 μM) against Mycobacterium tuberculosis H37Rv in vitro.