Kadsuphilols A-H, Oxygenated Lignans from Kadsura philippinensis

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• 作者：Ya-Ching Shen ; Yuan-Bin Cheng ; Ting-Wei Lan ; Chia-Ching Liaw ; Shorong-Shii Liou ; Yao-Haur Kuo ; Ashraf Taha Khalil
• 刊名：Journal of Natural Products
• 出版年：2007
• 出版时间：July 2007
• 年：2007
• 卷：70
• 期：7
• 页码：1139 - 1145
• 全文大小：108K
• 年卷期：v.70,no.7(July 2007)
• ISSN：1520-6025

文摘

Eight new oxygenated lignans, kadsuphilols A-H (1-8), were isolated from the leaves and stems of Kadsuraphilippinensis. Four of the isolated lignans (1-4) possess the normal C₁₈-dibenzocyclooctadiene skeleton, while theother four lignans (5-8) are C₁₉-homolignans possessing a substituted cyclohexadienone ring with a spiro-benzofuranoidmoiety. The structures of the isolated metabolites were elucidated through spectroscopic analyses, including 2D NMRexperiments. Compounds 1 and 4 are the first report of an R-biphenyl configuration with a mages/gifchars/beta2.gif" BORDER=0 ALIGN="middle">-oxygenated substituent atthe C-9 position. The in vitro radical-scavenging activities of these compounds using DPPH were tested and evaluated.Compound 3 exhibited more potent activity than vitamins C and E.