Psychrophilins E鈥揌 and Versicotide C, Cyclic Peptides from the Marine-Derived Fungus Aspergillus versicolor ZLN-60

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• 作者：Jixing Peng ; Huquan Gao ; Xiaomin Zhang ; Shuai Wang ; Chongming Wu ; Qianqun Gu ; Peng Guo ; Tianjiao Zhu ; Dehai Li
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：October 24, 2014
• 年：2014
• 卷：77
• 期：10
• 页码：2218-2223
• 全文大小：375K
• ISSN：1520-6025

文摘

Four new cyclic peptides, psychrophilins E鈥揌 (1鈥?b>4), possessing a rare amide linkage between the carboxylic acid in anthranilic acid (ATA) and the nitrogen from an indole moiety, along with a new ATA-containing hexapeptide, versicotide C (5), were obtained from the culture of the marine-derived fungus Aspergillus versicolor ZLN-60. The structures, including absolute configurations, were elucidated by a combination of HRESIMS, NMR, X-ray crystallography, TDDFT ECD calculations, and Marfey鈥檚 method. Versicotide C (5) is the first natural cyclic hexapeptide containing two anthranilic acids. Compounds 1鈥?b>5 were not cytotoxic, and compound 3 showed potent lipid-lowering effects.