Synthesis of 2-Aminobenzoxazoles Using Tetramethyl Orthocarbonate or 1,1-Dichlorodiphenoxymethane

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• 作者：Christopher L. Cioffi ; John J. Lansing ; Hamza Yksel
• 刊名：Journal of Organic Chemistry
• 出版年：2010
• 出版时间：November 19, 2010
• 年：2010
• 卷：75
• 期：22
• 页码：7942-7945
• 全文大小：772K
• 年卷期：v.75,no.22(November 19, 2010)
• ISSN：1520-6904

文摘

The synthesis of 2-aminobenzoxazoles can be readily achieved by two versatile, one-pot procedures utilizing commercially available tetramethyl orthocarbonate or 1,1-dichlorodiphenoxymethane, an amine, and an optionally substituted 2-aminophenol. The reactions were conducted under mild conditions and provided 2-aminobenzoxazoles in modest to excellent yields. A variety of amines and substituted 2-aminophenols were used to investigate the scope of the reactions.