Asymmetric Transamination of α-Keto Acids Catalyzed by Chiral Pyridoxamines

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• 作者：Xiaoyu Lan ; Chuangan Tao ; Xuliang Liu ; Aina Zhang ; Baoguo Zhao
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：August 5, 2016
• 年：2016
• 卷：18
• 期：15
• 页码：3658-3661
• 全文大小：396K
• 年卷期：0
• ISSN：1523-7052

文摘

A new type of novel chiral pyridoxamines 3a–g containing a side chain has been developed. The pyridoxamines displayed catalytic activity and promising enantioselectivity in biomimetic asymmetric transamination of α-keto acids, to give various α-amino acids in 47–90% yields with up to 87% ee’s under very mild conditions. An interesting effect of the side chain on enantioselectivity was observed in the reaction.