Electrochemically Modulated Nitric Oxide Release From Flexible Silicone Rubber Patch: Antimicrobial Activity For Potential Wound Healing Applications
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- 作者：Woong Hee Lee ; Hang Ren ; Jianfeng Wu ; Ondrej Novak ; Richard B. Brown ; Chuanwu Xi ; Mark E. Meyerhoff
- 刊名：ACS Biomaterials Science & Engineering
- 出版年：2016
- 出版时间：September 12, 2016
- 年：2016
- 卷：2
- 期：9
- 页码：1432-1435
- 全文大小：334K
- ISSN：2373-9878
文摘
Herein, we report a novel design and the antimicrobial efficacy of a flexible nitric oxide (NO) releasing patch for potential wound healing applications. The compact sized polydimethylsiloxane (PDMS) planar patch generates NO via electrochemical reduction of nitrite ions mediated by a copper(II)-ligand catalyst using a portable power system and an internal gold coated stainless steel mesh working electrode. Patches are fabricated via soft lithography and 3-D printing. The devices can continuously release NO over 4 days and exhibit potent bactericidal effects on both Escherichia coli and Staphylococcus aureus. The device may provide an effective, safe, and less costly alternative for treating chronic wounds.