Synthesis and Characterization of Multiblock Copolymers Based on Spider Dragline Silk Proteins

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• 作者：Chuncai Zhou ; Boxun Leng ; Jinrong Yao ; Jie Qian ; Xin Chen ; Ping Zhou ; David P. Knight ; Zhengzhong Shao
• 刊名：Biomacromolecules
• 出版年：2006
• 出版时间：August 2006
• 年：2006
• 卷：7
• 期：8
• 页码：2415 - 2419
• 全文大小：156K
• 年卷期：v.7,no.8(August 2006)
• ISSN：1526-4602

文摘

Spider dragline silk with its superlative tensile properties provides an ideal system to study the relationship betweenmorphology and mechanical properties of a structural protein. Accordingly, we synthesized two hybrid multiblockcopolymers by condensing poly(alanine) [(Ala)₅] blocks of the structural proteins (spidroin MaSp1 and MaSp2)of spider dragline silk with different oligomers of isoprene (2200 and 5000 Da) having reactive end groups. Thesynthetic multiblock polymer displayed similar secondary structure to that of natural spidroin, the peptide segmentforming a -sheet structure. These multiblock polymers showed a significant solubility in the component solvents.Moreover, the copolymer which contains the short polyisoprene segment would aggregate into a micellar-likestructure, as observed by TEM.