Diterpene Glycosides and Polyketides from Xylotumulus gibbisporus
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- 作者：Ya-Chih Chang ; Chung-Kuang Lu ; Yin-Ru Chiang ; Guei-Jane Wang ; Yu-Ming Ju ; Yueh-Hsiung Kuo ; Tzong-Huei Lee
- 刊名：Journal of Natural Products
- 出版年：2014
- 出版时间：April 25, 2014
- 年：2014
- 卷：77
- 期：4
- 页码：751-757
- 全文大小：345K
- 年卷期：v.77,no.4(April 25, 2014)
- ISSN：1520-6025
文摘
Four new tetracyclic diterpene glycosides, namely, sordarins C鈥揊 (1鈥?b>4), and three new 纬-lactone polyketides, namely, xylogiblactones A鈥揅 (5鈥?b>7), along with sordarin were isolated from the ethyl acetate extracts of the fermented broths of Xylotumulus gibbisporus YMJ863. The structures of 1鈥?b>7 were elucidated on the basis of spectroscopic data analyses. The configurations of 1鈥?b>4 were deduced by NOESY, molecular modeling, and comparison with the literature. The relative configurations of 5鈥?b>7 were deduced by X-ray crystallographic analysis of 5. Compounds 1鈥?b>5 and sordarin were evaluated in an antifungal assay using Candida albicans ATCC 18804, C. albicans ATCC MYA-2876, and Saccharomyces cerevisiae ATCC 2345, and only sordarin exhibited significant antifungal activities against these fungal strains, with MIC values of 64.0, 32.0, and 32.0 渭g/mL, respectively. The effect of compounds 1鈥?b>7 and sordarin on the inhibition of NO production in lipopolysaccharide-activated murine macrophages was also evaluated. Compounds 2 and sordarin inhibited NO production with IC50 values of 327.2 卤 46.6 and 157.1 卤 24.1 渭M, respectively.