A Facile Approach for the Asymmetric Synthesis of Oxindoles with a 3-Sulfenyl-Substituted Quaternary Stereocenter

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• 作者：Xiaowei Dou ; Bo Zhou ; Weijun Yao ; Fangrui Zhong ; Chunhui Jiang ; Yixin Lu
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：October 4, 2013
• 年：2013
• 卷：15
• 期：19
• 页码：4920-4923
• 全文大小：242K
• 年卷期：v.15,no.19(October 4, 2013)
• ISSN：1523-7052

文摘

With the employment of a threonine-incorporating multifunctional catalyst 9, Michael addition of 3-sulfenyloxindoles to nitroolefins proceeded stereoselectively, leading to the formation of oxindoles with a 3-sulfenyl-substituted quaternary center in excellent yields, and with high diastereoselectivities and excellent enantioselectivities.