Highly Regioselective Synthesis of Polysubstituted Pyrroles through Three-Component Reaction Induced by Low-Valent Titanium Reagent

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• 作者：Guolan Dou ; Chunling Shi ; Daqing Shi
• 刊名：Journal of Combinatorial Chemistry
• 出版年：2008
• 出版时间：November 10, 2008
• 年：2008
• 卷：10
• 期：6
• 页码：810-813
• 全文大小：99K
• 年卷期：v.10,no.6(November 10, 2008)
• ISSN：1520-4774

文摘

1,2,3,5-Tetrasubstituted and 1,2,3,4,5-pentasubstituted pyrroles may be synthesized through three-component reaction of 1,3-diketones, aldehydes, and amines induced by low-valent titanium reagent. High regioselectivity was achieved. Compared with the classical synthetic method, this new method has the advantages of short reaction time (15 min), high yields, convenient manipulation, and high regioselectivity.