Polyoxypregnane Steroids from the Stems of Marsdenia tenacissima

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• 作者：Sheng Yao ; Kenneth Kin-Wah To ; Ya-Zhou Wang ; Chun Yin ; Chunping Tang ; Stella Chai ; Chang-Qiang Ke ; Ge Lin ; Yang Ye
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：September 26, 2014
• 年：2014
• 卷：77
• 期：9
• 页码：2044-2053
• 全文大小：356K
• ISSN：1520-6025

文摘

A new polyoxypregnane aglycone, tenacigenin D (1), and seven new C₂₁ steroid glycosides, tenacissimosides D鈥揓 (2鈥?b>8), were isolated from the stems of Marsdenia tenacissima. Their structures were determined by interpretation of their 1D and 2D NMR and other spectroscopic data, as well as by comparison with published values for related known compounds. Compound 1 was found to circumvent P-glycoprotein (P-gp)-mediated multidrug resistance through an inhibitory effect on P-gp with a similar potency to verapamil. In addition, compound 1 potentiated the activity of erlotinib and gefitinib in epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI)-resistant non-small-cell lung cancer cells.