Anti-inflammatory Inositol Derivatives from the Whole Plant of Inula cappa

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• 作者：Jiewei Wu ; Chunping Tang ; Sheng Yao ; Lei Zhang ; Changqiang Ke ; Linyin Feng ; Ge Lin ; Yang Ye
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：October 23, 2015
• 年：2015
• 卷：78
• 期：10
• 页码：2332-2338
• 全文大小：296K
• ISSN：1520-6025

文摘

Twelve new inositol derivatives, classified into myoinositol (1鈥?b>6) and l-inositol (10鈥?b>15) types, along with five known analogues were isolated from the whole plant of Inula cappa. The structures of the new compounds were established by extensive analysis of mass spectrometric and 1D and 2D NMR spectroscopic data. All the tested compounds showed anti-inflammatory activities against the production of NO in RAW264.7 macrophages stimulated by lipopolysaccharide, with IC₅₀ values ranging from 7 to 23 渭M.