Catalytic Reduction of O2 by Cytochrome c Using a Synthetic Model of Cytochrome c Oxidase

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• 作者：James P. Collman ; Somdatta Ghosh ; Abhishek Dey ; Richard A. Decrau ; Ying Yang
• 刊名：Journal of the American Chemical Society
• 出版年：2009
• 出版时间：April 15, 2009
• 年：2009
• 卷：131
• 期：14
• 页码：5034-5035
• 全文大小：156K
• 年卷期：v.131,no.14(April 15, 2009)
• ISSN：1520-5126

文摘

Cytochrome c oxidase (CcO) catalyzes the four-electron reduction of oxygen to water, the one-electron reductant Cytochrome c (Cytc) being the source of electrons. Recently we reported a functional model of CcO that electrochemically catalyzes the four-electron reduction of O₂ to H₂O (Collman et al. Science 2007, 315, 1565). The current paper shows that the same functional CcO model catalyzes the four-electron reduction of O₂ using the actual biological reductant Cytc in a homogeneous solution. Both single and steady-state turnover kinetics studies indicate that O₂ binding is rate-determining and that O−O bond cleavage and electron transfer from reduced Cytc to the oxidized model complex are relatively fast.