CholesteroNitrones for Stroke

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• 作者：Maria I. Ayuso ; Mourad Chioua ; Emma Mart铆nez-Alonso ; Elena Soriano ; Joan Montaner ; Jaime Masju谩n ; Dimitra J. Hadjipavlou-Litina ; Jos茅 Marco-Contelles ; Alberto Alc谩zar
• 刊名：Journal of Medicinal Chemistry
• 出版年：2015
• 出版时间：August 27, 2015
• 年：2015
• 卷：58
• 期：16
• 页码：6704-6709
• 全文大小：324K
• ISSN：1520-4804

文摘

This study describes CholesteroNitrone 2 as an antioxidant and neuroprotective agent against ischemic injury. Neuroprotection was assessed using in vitro and in vivo experimental ischemia models. The compound significantly increased cell viability, induced neuroprotection following ischemic reperfusion, and decreased neurological deficit scores in treated animals, supporting the next preclinical studies as a potential agent for the treatment of stroke.