Application of PAT Tools for the Safe and Reliable Production of a Dihydro-1H-imidazole

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• 作者：Ana C. Barrios Sosa ; Ryan Conway ; R. Thomas Williamson ; James P. Suchy ; William Edwards ; Thomas Cleary
• 刊名：Organic Process Research & Development
• 出版年：2011
• 出版时间：November 18, 2011
• 年：2011
• 卷：15
• 期：6
• 页码：1458-1463
• 全文大小：928K
• 年卷期：v.15,no.6(November 18, 2011)
• ISSN：1520-586X

文摘

The application of two Process Analytical Technology (PAT) tools was studied and implemented for the safe and reliable synthesis of an advanced intermediate (4S,5R-7) of a member of the dihydro-1H-imidazole (1) class of compounds. Real time data were generated using ReactIR to track the complete breakdown of phosgene precursors (2) to phosgene (3) and confirm the absence of these hazardous materials prior to batch transfer operations. In addition, the chiral resolution by crystallization of rac7 was monitored by a Lasentec FBRM probe-based system. Implementation of the latter helped to track the crystallization process to minimize the risk of cocrystallization of undesired isomer 4R,5S-7.